[CAS NO. 21339-55-9] (S)-Indoximod
PRODUCTS SPECIFICATIONS [21339-55-9]
DESCRIPTION [21339-55-9]
Overview
| MDL | MFCD00467133 |
|---|---|
| Molecular Weight | 218.25 |
| Molecular Formula | C12H14N2O2 |
| SMILES | N[C@@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O |
Summary
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) . (S)-Indoximod can be used for the research of cancer [1] [2] .
IC50 & Target
Indoleamine 2,3-Dioxygenase (IDO) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 5 mg/mL ( 22.91 mM ; ultrasonic and adjust pH to 5 with HCl)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.5819 mL | 22.9095 mL | 45.8190 mL |
| 5 mM | 0.9164 mL | 4.5819 mL | 9.1638 mL |
| 10 mM | 0.4582 mL | 2.2910 mL | 4.5819 mL |
References
- [1] Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.
- [2] Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.
Synonyms