[CAS NO. 21645-51-2] Aluminum Hydroxide
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PRODUCTS SPECIFICATIONS [21645-51-2]
Catalog
HY-B1521
Brand
MCE
CAS
21645-51-2
DESCRIPTION [21645-51-2]
Overview
| MDL | MFCD00003420 |
|---|---|
| Molecular Weight | 78.00 |
| Molecular Formula | AlH3O3 |
| SMILES | O[Al](O)O |
For research use only. We do not sell to patients.
2 Publications Citing Use of MCE
Summary
Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines [1] [2] .
In Vivo
Aluminum Hydroxide (orally; 100 mg/kg/day for 7 days) increases lipid peroxidation and decreases the activity of SOD in the brain. Aluminum Hydroxide can dissolve in distilled water to be a homogeneous suspension [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00031109 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Not Applicable | |
| NCT01837446 | Isfahan University of Medical Sciences |
Stomatitis
|
July 2011 | Phase 2|Phase 3 |
| NCT00000809 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections|HIV Seronegativity
|
Phase 1 | |
| NCT01376765 | National Institute of Allergy and Infectious Diseases (NIAID) |
SARS
|
Phase 1 | |
| NCT04915768 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
May 3, 2021 | Phase 1 |
| NCT03755427 | Shanghai Institute Of Biological Products |
H7N9 Influenza
|
November 2018 | Phase 2 |
| NCT00854776 | Taipei Veterans General Hospital, Taiwan |
Peptic Ulcer|Ulcer Complications
|
January 2009 | Not Applicable |
| NCT02298179 | GlaxoSmithKline |
Respiratory Syncytial Virus (RSV)
|
December 19, 2014 | Phase 1 |
| NCT00001906 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Cutaneous Leishmaniasis
|
April 1999 | Phase 1 |
| NCT03589768 | National Institute of Allergy and Infectious Diseases (NIAID) |
Clostridium Difficile Immunisation|Diphtheria|Diphtheria Immunisation|Pertussis|Tetanus|Tetanus Immunisation
|
January 24, 2019 | Phase 2 |
| NCT00280033 | National Institute of Allergy and Infectious Diseases (NIAID) |
Influenza
|
February 2006 | Phase 1|Phase 2 |
| NCT00974935 | National Institute of Allergy and Infectious Diseases (NIAID) |
Toxic Shock Syndrome Staphylococcal
|
February 2011 | Phase 1 |
| NCT02116998 | Genocea Biosciences, Inc. |
Pneumococcal Infections|Pneumonia, Pneumococcal
|
September 2014 | Phase 2 |
| NCT00263744 | MedImmune LLC|GlaxoSmithKline |
Healthy
|
November 1999 | Phase 1|Phase 2 |
| NCT00000779 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Phase 1 | |
| NCT05561673 | GlaxoSmithKline |
Hepatitis B
|
October 4, 2022 | Phase 1|Phase 2 |
| NCT00001042 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Phase 1 | |
| NCT00529399 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institute of Allergy and Infectious Diseases (NIAID)|National Center for Research Resources (NCRR)|American Diabetes Association|Juvenile Diabetes Research Foundation |
Type 1 Diabetes Mellitus
|
February 2009 | Phase 2 |
| NCT00001052 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Phase 1 | |
| NCT03382418 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
December 27, 2017 | Phase 1 |
| NCT00296634 | National Institute of Allergy and Infectious Diseases (NIAID) |
Influenza
|
March 2006 | Phase 1|Phase 2 |
| NCT00294099 | National Institute of Allergy and Infectious Diseases (NIAID) |
Influenza
|
March 2006 | Phase 1|Phase 2 |
| NCT01280968 | Alexey Mukhin|Wake Forest University Health Sciences|Novartis Pharmaceuticals|Duke University |
Nicotine Dependence
|
December 2010 | Phase 2 |
| NCT00002402 | VaxGen|NIH AIDS Clinical Trials Information Service |
HIV Infections
|
Phase 1 | |
| NCT00000868 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections|HIV Seronegativity
|
Phase 1 | |
| NCT02067676 | U.S. Army Medical Research and Development Command|Walter Reed Army Institute of Research (WRAIR) |
Campylobacter Infection
|
April 21, 2014 | Phase 1 |
| NCT00001053 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Phase 1 | |
| NCT03369808 | Shanghai Institute Of Biological Products|Henan Center for Disease Control and Prevention |
H7N9 Influenza
|
December 29, 2017 | Phase 1|Phase 2 |
| NCT00018135 | National Center for Research Resources (NCRR) |
Renal Failure
|
Not Applicable | |
| NCT03049488 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Respiratory Syncytial Virus
|
February 22, 2017 | Phase 1 |
| NCT00533741 | National Institute of Allergy and Infectious Diseases (NIAID) |
Coronavirus (SARS-CoV)
|
Phase 1 | |
| NCT05131295 | El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez |
Subarachnoid Hemorrhage|Brain Ischemia|Subarachnoid Hemorrhage, Aneurysmal|Aneurysmal Subarachnoid Hemorrhage|Delayed Cerebral Ischemia|Vasospasm, Cerebral
|
September 5, 2007 | Phase 3 |
| NCT00001044 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Phase 1 | |
| NCT00382980 | National Institute of Allergy and Infectious Diseases (NIAID) |
Influenza
|
October 2006 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
In Vitro:
DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
In Vivo:
-
1.
Add each solvent one by one: 0.5% CMC-Na /saline water
Solubility: 10 mg/mL (128.21 mM); Suspended solution; Need ultrasonic
*
All of the co-solvents are available by MCE.
References
- [1] He P, et al. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccin Immunother. 2015;11(2):477-88.
- [2] Amini Y, et al. Aluminum hydroxide nanoparticles show strong activity to stimulate Th-1 immune response against tuberculosis. Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1331-1335.
- [3] Ohtawa M, et al. Effect of aluminum ingestion on lipid peroxidation in rats. Chem Pharm Bull (Tokyo). 1983 Apr;31(4):1415-8.
Synonyms
Aluminum hydroxide (Al(OH)3)
Aluminum hydroxide
Alusal
Aluminum trihydroxide
Amberol ST 140F
C 4D
H 46
Higilite H 31S
Higilite H 42
Higilite
Hydral 705
Alcoa C 30BF
Alcoa 331
Hychol 705
Hydral 710
GHA 332
C 31F
C 31C
P 30BF
C 33
Baco AF 260
AF 260
Alcoa C 333
Higilite H 32
Alumigel
GHA 331
Martinal F-a
GHA 431
Alcoa C 330
Calmogastrin
F 1000
Martinal A
Martinal A/S
Hydrafil
Alugel
Martinal BM 2
Martinal C
Martinal E
Martinal X
GHA 131
GHA 731
H 31
Hydroxal
Higilite H 32S
Baco FRF 80S5
Baco FRF-LV 1S5
RH 31F
Alcoa AS 301
Higilite H 42M
Aluminum oxide (Al2O3), trihydrate
Apyral 2
Aluminic acid (H3AlO3)
Apyral 8
Apyral 15
Apyral 60
Higilite H 31
Higilite H 32IX
Higilite H 10
BMZ
Alcoa 710
SB 632
Higilite HWC
Hydral PGA
Paperad
Alhydrogel
Higilite H 42S
Higilite H 41
H 42
Hydrated alumina
CW 308
DT 079
Higilite H 40
Reheis F 1000
Mucogel
F 2000
C 303
Higilite H 43M
Higilite 42S
Higilite H 310
Amphogel
B 703
Higilite H 320
C 308
Higilite H 30
CHP 340S
Higilite H 32I
B 1403
H 21
Martinal OL 111
Higilite 42M
CE 30E
Higilite H 311
Apyral B
Apyral B 2
Baco FRF 40
B 1403S
Alternagel
Baco FRF 20
RH 730
Micral 932
Apyral 4
Apyral 40
Baco AF 230
Apyral B 90
Alcoa C 331
Higilite H 34
Higilite H 34HL
B 103 (hydroxide)
B 103
SB 136
HWC
Hydral 710B
Apyral 90
Amphojel
Martinal ON 313
Alolt 8
Trihydroxyaluminum
Baco FRF 80
Apyral 120VAW
Martifin
AC 450
Alcoa C 33
C 12
Ultrafine 35E
Ultrafine 25E
Ultrafine 15E
Pepsamar
Alugelibys
Martinal OL 104
Martinal VPF 8907
Martinal OL 107
Apyral B 60
Hydral 700
Baco FRF 85
Trihyde OL 104
SF 11
UF 35E
Hydral 710W
Higilite H 100
H 32
Alumina trihydrate
C 31
Alcoa C 31
Higilite H 10C
Baco SF 7S3A
C 301 (hydroxide)
C 301
HAL 42
Tomix AD 220
Higilite H
SpaceRite S 11ATH
H 30C
BW 103
Liquigel
Apyral 120
Higilite H 32TX
CL 303
Higilite H 320ST
Martinal F
SB 432
Alolt 90
Alolt 80
LA (filler)
LA 5
S 100 (filler)
FM (filler)
S 100
FM
LA
BW 53
Martinal ON 320
Higilite H 210
Higilite H 43
CW 325
C 303H
C 315H
H 310ST
AC 714KC
Alcoa H 65
CL 310 (hydroxide)
CL 310
Higilite H 42H
B 700
Micral 855
Micral 916
B 303
B 153
Aluminum oxide trihydrate
C 325 (hydroxide)
C 325
C 315
SpaceRite S 3ATH
Spheralite 509A
HAL 43
Martinal ON 310
Higilite H 43S
Higilite HBT 320
Apyral 24
CW 380S
C 333
C 303 (hydroxide)
Higilite H 141
C 308 (hydroxide)
Trikup 710B
Higilite H 21
Higilite HS 320ST
H 42ST
H 34L
Alcoa C 385
AKP-DA
SF 7
CW 375HT
CW 350
CW 315
SpaceRite S 23ATH
CW 325LV
F 2000 (hydroxide)
H 42M
A 3011
B 703S
Kyowaad S 200S
Solem OE 431
Reheis F 2000
ATH-CM 432
Martinal OL 921
F 1000 (pharmaceutical)
Higilite H 42I
CWL 326S
CW 308S
Higilite H 320I
Martinal 104C
Alcoa A 325
H 320
ATH 30
Antipollon HT
Takallophane
H 31I
C 385
Solem SB 36
Solem SB 632
Higilite H 52M
B 513
C 301R
CE 300A
Higilite NB 1
B 53
Apyral 25
B 53 (hydroxide)
ATH-SH 5
Apyral
C 12 (hydroxide)
BX 103V15
BW 153
Higilite HS 310
C 303E
Martinal ON 921
OC 2000
H 210
ON 313
HBT 320
ATH-X
AE 107
Higilite H 31I
BS 33
Baco S 5
Camag 5015A
Higilite 42
BW 153ST
C 710B
Martifil P 2
Martinal OL 104LE
SSF 11
ATH-FR
Micral 9400
Micral 1500
Micral 632
H 43M
Micral 1440
CWL 310
RF 2071
Rehydragel HPA
Rehydragel
Martinal OL 103C
CW 310SH
CWL 325J
H 320ST
CWL 325B
HS 310
H-WP
Micral 932CM
UF-ATH 250
CW 325J
H 43S
H 42S
Solem SB 336
OL 111
Martinal ON 4608
ON 4608
Superfine 7E
Baco Superfine 7
Baco SF 7
Martifin OL 107
OL 107
SpaceRite S 11
BW 103ST
HS 320
SF 11 (hydroxide)
SF 7E
FlameGard M 15B
SB 336
RC 325
ATH 60
ATH 130
ATH 632SH1
B 303C
H 310
Martinal TS 601
Onyx Elite
H 710
Higilite H 42STE
Higilite 42STE
42STE
Superfine 11E
BW 33ST
BW 33
XL 10MR
XL 20MR
Omya ON 921
C 302A
B 308
Alolt 50AF
Alolt 59
Alolt 60FLS
Higilite H 24M
Martinal 906
Higilite HS 32
HS 32
C 308E
C 3005
CW 325A
CL 302
H 32I
H 42I
CL 302 (hydroxide)
Dispersal 14/2
Higilite 43M
B 315
Martinal ON 904LV
Martinal ON 901
B 325
B 30S
B 325 (hydroxide)
B 30S (hydroxide)
H 308B
Higilite H 308B
H 308B (hydroxide)
HP 600
Alcan SF 4
Hydral H 710
Hydral H 716
SF 4
BF 013
Hymod 632
Apyral 40E
RF 22
CM 45
GL 303
CM 45 (filler)
Dialume
H 308
Apyral 40CD
Apyral 40D
B 01319
H 421
Superfine SF 4
HS 330
Apyral 60D
Rehydragel LV
NSC 664400
Hydralcoat
Martinal 104
H 10
CL 320
Higilite H 43STE
Martinal OL 107C
Genbrite 700
Martinal ON 904
Martinal ON 908
ON 921
ON 904
RH 30
Alcoa OC 1000
Techtonite HT
H 34HL
JHK-M 10
CW 316
ZX 131
B 103E
CS 600
CS 600 (hydroxide)
AC 400
AC 400 (hydroxide)
BHP 26
SB 805
Terracess BMP
Apyral 16
BF 083
PGASD
Securoc A 32
Higilite H 432ST
CW 325B
Martinal OL 104G
NOC 30
RH 40
TS 601
BK 153
UFH 20
ALH
CL 310SP
Dispal 40
Higilite H 421STE
OL 107C
Alumina hydrate
Cataloid AAS 3
Dispal 23N4
Excemite 60
SH 150/01
Aluminum oxide hydrate
Alfrimal 437
Higilite H 100ME
H 100ME
UFH 40
H 34
DP 6033
Apyral MD 40
Baco SF 11E
AC 470
Higilite HS 330
Terracess BMI
Higilite H 341
C 305
Securoc A 5FS41.0
B 103ST
LA 5 (hydroxide)
Martinal ON 021
H 43STE
Higilite HM 42
Alfrimal 103
C 231
A 02
HP 360
Onyx Elite 100
Hymod SB 432CM
H 73
B 1403T
Martinal OL 104WE6
OL 104WE
Martinal OL 104WE
SB 332
BE 033
Alumill F 505
FR 4
Higilite H-W
CL 303Y
FR 4 (hydroxide)
Martifin OL
Portaflame SG 40
Alolt 38AF
Martinal OL 107LE
Martinal OL 111LE
ATH-S 3
Aluminum hydroxide gel
Hydrated aluminum oxide
Martingloss
WHA 401
B 313
BF 013S
HP 350
HP 32
HP 42M
HP 43M
Trefil 774
C 310
R-Flam 9(3)
B 103S
CL 303M
B 73 (hydroxide)
B 73
BT 200
Martinal 107
EM 5075
Alum
Martinal OL 104LEO
Martinal OL 107LEO
H 43
Higilite H 43H
D 50
D 50 (hydroxide)
B 153E
Hymod M 932SG
CAM 9080
Hydral Coat 5
H 10CF
SB 222
Higilite H 100M
H 100M
Martinal Char 42
Hydral Coat 7
H 43H
Higilite H 425
Martinal OL 104A
OL 104A
HD 360
WA 1 (hydroxide)
WA 1
Alolt 60DLS
HS 341
BT 703ST
Alcoa C 320
Apyral 30CD
Barcroft 0200
Barcroft 0250
Scar-Let 104
Hubercarb SB 122
40CD
BF 013TV
Apyral 120E
Apyral 200SM
Apyral 60CD
B 153T
Apyral AOH 20
ATH 100
CW 350B
Martinal OL 104CL
TS 610
OL 104LE
Safic Alcan SF 4
Apyral 1E
Apyral 2E
Apyral 20X
Higilite H 32M
GD 00
AS 5
PPP 33
AS 5 (hydroxide)
Titan 4E
Higilite 421
Scarlet 315
Alolt 60F
HWF 1
ATH 2
Higilite HP 350
SB 122
WA 21
OL 104G
ATH 9400
Apyral SM 200
Apyral NH 20
SB 30SLM035
LE 0104
Higilite 360
Portaflame SG 200
Onyx Premier OP 25
Onyx Premier WP 31
Almorix B 316
H 32M
Martinal 107LEO
C 300GT
CM 450
C 3250
SH-M 25SP
ALH-F
ALH 3L
OL 104
Fiberline 489
Alumill MF 132
YH 24
H-WF 8SP
BF 103 (hydroxide)
BF 103
CW 313SH
Portafill A 40
HT 980
Reflamal S 30
Higilite HS 320
AD 200P
H 310ST-TO
Higilite M 43
BE 023
Higilite H 43W
Higilite 43W
BF 013STV
Almorix B 350
KH 101
KH 101 (hydroxide)
Alcan WH 311
H 100
MOLDX-A 100
H-WF 08A
HJM 8
Apyral 22
Hymod SB 805SP
Higilite H 42STM
SH 17W
HF 1
H 10M
AH 2
C 301N
WC 1
104LEO
PAX 140
Disperal BT
KH 101LP
107LEO
ATH-B
Framial 05
BP 083
B 30
Almorix B 30
H 24I
SH 15
SH 20
SH 100
SH 30N
OL 104LEO
ATH-C
Higilite S 48TV
BX 053T
Aluxid
ATH 4
YP 00050
HN 434
ATH
Apyral 33
Higlite H 42S
H-WF 50SP
101LC
AluMill F 280
BA 103
FR 3815
B 309
Onyx Elite 805
Alfrimal 447S
ATH-HN 434
ATH-MODX-P 18
FR 556
AD 200
Tomix AD 200
HJ 1000
Apyral 100SM
Onyx Elite 95
Onyx Elite 300
TL 8
H-WF 01SP
SB 303
H-WF 15A
H-WF 90
Micral AM 500
MoldX P 18
Hymod M 6400
Micral 9400D
SpaceRite S 3
V 101
Hydral PGA-SD
Weide V 101
Alfrimal 106
C 303N
SB 73
SB 153
Apyral 210
Highlite H 32
C 301CN
SB 143
HT 205
Aparyl B
ATHG 10
ON 310
AL-B 143
Hymod SB 432
ATH-SH 20
MoldX A 110
HCW 101
FA 50K
VK-LA 50
SB 93
HYDIRITE H-43M
FA 80
Almorix B 325
Higilite HC 32
Hydrafill 744-800
VKD 101V
WF 1
FA 70A
Apyral AG
ATH 104E
SG 200
OSDH 3
ATH-G 200
Alfrimal 446
Aluprem TGR 2
Portaflame SG 25
Trigal A 05P
Trigal A 05N
SB 93C
Apyral 200
AH 01DG
AH 1
AH 1 (hydroxide)
FR 3803
AH 01
FA 50
AH 01 (hydroxide)
KH 101HRT
FA 50 (hydroxide)
CG-ATH
JATH 0030E
BX 043T
SB 103T
ACW 1500
XH 056
AH 0107
TS 305
Alolt 59AF
HWF 2N
Onyx Pro 25
I 92612115
AH 3
LD 72Al
LD 74Al
LD 76Al
AH 3 (hydroxide)
QL 100
FRAT 44
FA 100
FR 3810
FR 3801
FR 3807
Huaya LA 4
FA 100 (hydroxide)
XS-ACW 5
XS-ACW 8
XS-ACW 10
ACW 5
ACW 8
ACW 10
VKD 06T
BW 53ST
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