[CAS NO. 216974-75-3]  Bevacizumab

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PRODUCTS SPECIFICATIONS [216974-75-3]

Catalog
HY-P9906
Brand
MCE
CAS
216974-75-3

DESCRIPTION [216974-75-3]

Overview

MDL-
Molecular Weight149 kDa(Average)
Molecular Formula-
SMILES[Bevacizumab]

For research use only. We do not sell to patients.


Summary

Bevacizumab, a humanized IgG1 monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity.


IC50 & Target

VEGF [1]


In Vitro

Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity, and inhibits its interaction with VEGFR-1 and VEGFR-2 [1] . Experimental analysis shows that the EC 50 of Bevacizumab to bind VEGF analyzed by ELISA is 0.18 μg/mL. Binding kinetics assays show similar results that Bevacizumab inhibits the VEGF-induced proliferation of HUVEC with an IC 50 value of 0.047±0.0081 μg/mL [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

It is demonstrated that the subconjunctival administration of FD006 and Bevacizumab can significantly inhibit CoNV in NaOH cauterized rats compared with the control group (p < 0.01) [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT00482495 Mayo Clinic|National Cancer Institute (NCI)
Multiple Myeloma and Plasma Cell Neoplasm
April 2006 Phase 2
NCT04843943 Fudan University
Hepatocellular Carcinoma
May 1, 2021 Phase 1|Phase 2
NCT03476798 University of Oklahoma|Clovis Oncology, Inc.
Cervical Cancer|Endometrial Cancer
June 29, 2018 Phase 2

Appearance

Liquid


Storage

Please store the product under the recommended conditions in the Certificate of Analysis.