[CAS NO. 2173232-79-4] LOM612
PRODUCTS SPECIFICATIONS [2173232-79-4]
DESCRIPTION [2173232-79-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 258.30 |
| Molecular Formula | C13H10N2O2S |
| SMILES | O=C1C2=C(SN=C2N(C)C)C(C3=CC=CC=C31)=O |
Summary
LOM612 is a potent FOXO relocator, with an EC 50 value of 1.5 μM in U2fox RELOC cells [1] .
IC50 & Target
EC50: 1.5 μM (FOXO, in U2fox RELOC cells) [1]
In Vitro
LOM612 potently activates nuclear translocation of FOXO with an EC 50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC 50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC 50 , 2.76 μM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 6 mg/mL ( 23.23 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.8715 mL | 19.3573 mL | 38.7147 mL |
| 5 mM | 0.7743 mL | 3.8715 mL | 7.7429 mL |
| 10 mM | 0.3871 mL | 1.9357 mL | 3.8715 mL |