[CAS NO. 219793-45-0] BTB06584
PRODUCTS SPECIFICATIONS [219793-45-0]
DESCRIPTION [219793-45-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 417.82 |
| Molecular Formula | C19H12ClNO6S |
| SMILES | ClC1=CC=C(C(OC2=C([N+]([O-])=O)C=CC(S(C3=CC=CC=C3)(=O)=O)=C2)=O)C=C1 |
2 Publications Citing Use of MCE
Summary
BTB06584 is a selective and IF1-dependent mitochondrial F 1 F o -ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death [1] .
IC50 & Target
Mitochondrial F 1 F o -ATPase [1]
In Vitro
In HL-1 cells, BTB06584 (100 μM) inhibits F
1
F
o
-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm ) or O
2
consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced
[1]
.
BTB06584 efficiency is increased by IF1 overexpression and reduced by silencing the protein
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BTB06584 (1 μM; 24 hours) treatment rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. The concentrations of BTB06584 that restore haemoglobin biosynthesis also alter mitochondrial bioenergetics in living fish [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 47 mg/mL ( 112.49 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3934 mL | 11.9669 mL | 23.9338 mL |
| 5 mM | 0.4787 mL | 2.3934 mL | 4.7867 mL |
| 10 mM | 0.2393 mL | 1.1967 mL | 2.3934 mL |
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1.