[CAS NO. 219832-49-2] MP-A08
PRODUCTS SPECIFICATIONS [219832-49-2]
DESCRIPTION [219832-49-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 519.64 |
| Molecular Formula | C27H25N3O4S2 |
| SMILES | O=S(C1=CC=C(C)C=C1)(NC2=CC=CC=C2/C=N/C3=CC=CC=C3NS(=O)(C4=CC=C(C)C=C4)=O)=O |
Summary
In Vitro
MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MP-A08 suppresses the growth of human lung tumor xenografts in mice.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 96.22 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9244 mL | 9.6220 mL | 19.2441 mL |
| 5 mM | 0.3849 mL | 1.9244 mL | 3.8488 mL |
| 10 mM | 0.1924 mL | 0.9622 mL | 1.9244 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.81 mM); Clear solution
References
- [1] Pitman MR et al. A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 2015 Mar 30, 6(9):7065-83.
- [2] Dimasi DP et al. Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation, 2016 Apr, 23(3):248-65.