[CAS NO. 2202738-42-7]  USP7-IN-3

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PRODUCTS SPECIFICATIONS [2202738-42-7]

Catalog
HY-112128
Brand
MCE
CAS
2202738-42-7

DESCRIPTION [2202738-42-7]

Overview

MDL-
Molecular Weight568.59
Molecular FormulaC29H31F3N6O3
SMILESO=C(N1CCC(CN2C(C3=NN(C)C(C4=CC=C(CN)C=C4)=C3N=C2)=O)(O)CC1)C[C@@H](C(F)(F)F)C5=CC=CC=C5

For research use only. We do not sell to patients.

Summary

USP7-IN-3 (Compound 5) is a potent and selective allosteric ubiquitin-specific protease 7 ( USP7 ) inhibitor [1] .


IC50 & Target

USP7 [1]


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 90 mg/mL ( 158.29 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7587 mL 8.7937 mL 17.5874 mL
5 mM 0.3517 mL 1.7587 mL 3.5175 mL
10 mM 0.1759 mL 0.8794 mL 1.7587 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 4.5 mg/mL (7.91 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.5 mg/mL (7.91 mM); Clear solution

* All of the co-solvents are available by MCE.