[CAS NO. 22055-22-7] Diphyllin
PRODUCTS SPECIFICATIONS [22055-22-7]
DESCRIPTION [22055-22-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 380.35 |
| Molecular Formula | C21H16O7 |
| SMILES | O=C1OCC2=C(O)C3=CC(OC)=C(OC)C=C3C(C4=CC=C(OCO5)C5=C4)=C12 |
Summary
Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus [1] . Diphyllin is a vacuolar type H + -ATPase (V-ATPase) inhibitor with an IC 50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts [2] . Diphyllin inhibits NO production with an IC 50 of 50 μM and has anticancer and anti-inflammatory activities [3] .
IC50 & Target
|
HIV-1 0.38 μM (IC 50 ) |
Vacuolar type H + -ATPase 17 nM (IC 50 ) |
Vesicular stomatitis virus (VSV)
|
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 14.29 mg/mL ( 37.57 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6292 mL | 13.1458 mL | 26.2916 mL |
| 5 mM | 0.5258 mL | 2.6292 mL | 5.2583 mL |
| 10 mM | 0.2629 mL | 1.3146 mL | 2.6292 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution
References
- [1] Xin-Ya Xu, et al. Anti-HIV Lignans From Justicia Procumbens. Chin J Nat Med. 2019 Dec;17(12):945-952.
- [2] Mette G Sørensen, et al. Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption. J Bone Miner Res. 2007 Oct;22(10):1640-8.
- [3] Yerra Koteswara Rao, et al. Anti-inflammatory Activities of Constituents Isolated From Phyllanthus Polyphyllus. J Ethnopharmacol. 2006 Jan 16;103(2):181-6.
Synonyms