[CAS NO. 2216764-29-1] CD73-IN-4
PRODUCTS SPECIFICATIONS [2216764-29-1]
DESCRIPTION [2216764-29-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 463.81 |
| Molecular Formula | C16H23ClN5O7P |
| SMILES | ClC1=NC(N([C@@H]([C@H](O)[C@@H]2O)O[C@@H]2COCP(O)(O)=O)N=C3)=C3C(NC4CCCC4)=N1 |
Summary
IC50 & Target
CD73 [1]
In Vitro
CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC
50
= 0.86 nM) and soluble mouse CD73 (mCD73; IC
50
= 3.0 nM), CHO cells overexpressing hCD73 (IC
50
= 2.6 nM) or mCD73 (IC
50
= 13 nM), and the human ovary cancer cell line SKOV-3 (IC
50
= 0.55 nM). It exhibits excellent selectivity (IC
50
> 10 000 nM) against CD39, A2aR, and NTPDase2, 3, and 8
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 269.51 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1561 mL | 10.7803 mL | 21.5606 mL |
| 5 mM | 0.4312 mL | 2.1561 mL | 4.3121 mL |
| 10 mM | 0.2156 mL | 1.0780 mL | 2.1561 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution