[CAS NO. 2219320-08-6] MSC1094308
PRODUCTS SPECIFICATIONS [2219320-08-6]
DESCRIPTION [2219320-08-6]
Overview
| MDL | MFCD31814427 |
|---|---|
| Molecular Weight | 462.55 |
| Molecular Formula | C29H29F3N2 |
| SMILES | FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1 |
Summary
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC 50 values of 0.71 μM and 7.2 μM for VPS4B and p97 , respectively [1] . MSC1094308 inhibits the D2 ATPase activity by binding to a drugable hotspot of p97 . MSC1094308 can be used in study of cancer [1] .
IC50 & Target
IC50: 0.71 μM (VPS4B), 7.2 μM (p97) [1] .
In Vitro
MSC1094308 (10 µM; 8 h) induces accumulation of polyubiquitin as a biomarker for degradation inhibition in HCT116 cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | HCT116 cells |
| Concentration: | 10 µM |
| Incubation Time: | 8 h |
| Result: | Led to accumulation of polyubiquitinated proteins (a biomarker for degradation inhibition). |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 108.10 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1619 mL | 10.8096 mL | 21.6193 mL |
| 5 mM | 0.4324 mL | 2.1619 mL | 4.3239 mL |
| 10 mM | 0.2162 mL | 1.0810 mL | 2.1619 mL |