[CAS NO. 22199-08-2] Silver sulfadiazine
PRODUCTS SPECIFICATIONS [22199-08-2]
DESCRIPTION [22199-08-2]
Overview
| MDL | MFCD00072101 |
|---|---|
| Molecular Weight | 357.14 |
| Molecular Formula | C10H9AgN4O2S |
| SMILES | NC(C=C1)=CC=C1S2(=O[Ag+][N]3=CC=C[N-]C3=N2)=O |
Summary
Silver sulfadiazine (AgSD), a sulfonamide antibiotic , effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis . The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication [1] .
In Vitro
Silver sulfadiazine (AgSD) is a topical antibiotic used to the research of bacterial infection in burns [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02116010 | Pherecydes Pharma |
Wound Infection
|
July 2015 | Phase 1|Phase 2 |
| NCT02109718 | University of the Philippines|Committee on Research Implementation and Development |
Superficial Partial Thickness Burns
|
January 2009 | Phase 3 |
| NCT03162367 | SCARM Institute, Tabriz, Iran |
Burn
|
April 10, 2019 | Phase 2 |
| NCT04391582 | Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara |
Burns
|
May 1, 2017 | Phase 2 |
| NCT02108535 | University of Sorocaba |
Second-degree Burn
|
November 2013 | Phase 4 |
| NCT04601532 | J. Peter Rubin, MD|Synedgen, Inc|United States Department of Defense|University of Pittsburgh |
Superficial Partial Thickness Burn
|
June 11, 2021 | Phase 4 |
| NCT01553708 | Chulalongkorn University|National Science and Technology Development Agency, Thailand |
Deep Partial Thickness Burn
|
December 2011 | Phase 2|Phase 3 |
| NCT05073172 | OHSU Knight Cancer Institute|Oregon Health and Science University |
Breast Carcinoma|Head and Neck Carcinoma|Radiation-Induced Dermatitis
|
December 1, 2022 | Not Applicable |
| NCT01926392 | University of Virginia |
Burn
|
April 2011 | Phase 4 |
| NCT04202289 | Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara |
Burns
|
April 3, 2017 | Phase 3 |
| NCT03564795 | KeraNetics, LLC|Wake Forest University|United States Department of Defense |
Partial-thickness Burn
|
August 31, 2018 | Not Applicable |
| NCT00641433 | Rosalind Franklin University of Medicine and Science |
Ingrown Nail
|
November 2005 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
H 2 O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
References
- [1] Strydom SJ, et al. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine. 2013;9(1):85-93.
- [2] Munhoz DR, et al. Alginate films functionalized with silver sulfadiazine-loaded [Mg-Al] layered double hydroxide as antimicrobial wound dressing. Int J Biol Macromol. 2019;141:504-510.
Synonyms