[CAS NO. 22246-18-0] 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone

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PRODUCTS SPECIFICATIONS [22246-18-0]

Catalog

HY-W010130

Brand

MCE

CAS

22246-18-0

DESCRIPTION [22246-18-0]

Overview

MDL	MFCD06410891
Molecular Weight	163.17
Molecular Formula	C9H9NO2
SMILES	O=C1NC2=C(C=CC(O)=C2)CC1

For research use only. We do not sell to patients.

Summary

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC ₅₀ of 183 μM, and has no effect on MAO-B ^[1] .

IC50 & Target

IC50: 183 μM (MAO-A) ^[1]

In Vitro

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 612.86 mM ; Need ultrasonic)

H ₂ O : 1 mg/mL ( 6.13 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1286 mL	30.6429 mL	61.2858 mL
5 mM	1.2257 mL	6.1286 mL	12.2572 mL
10 mM	0.6129 mL	3.0643 mL	6.1286 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (15.32 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (15.32 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (15.32 mM); Clear solution
4.

Add each solvent one by one: PBS

Solubility: 1 mg/mL (6.13 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Meiring L, et al. Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5498-502.

Synonyms

2(1H)-Quinolinone, 3,4-dihydro-7-hydroxy-

Carbostyril, 3,4-dihydro-7-hydroxy-

Hydrocarbostyril, 7-hydroxy-

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

7-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone

7-Hydroxy-3,4-dihydrocarbostyril

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone

7-Hydroxy-3,4-dihydro-1H-quinolin-2-one

3,4-Dihydro-7-hydroxy-2(1 H)-quinoline

3,4-Dihydro-quinoline-2,7-diol

3,4-Dihydroquinoline-2,7-diol