[CAS NO. 2225824-53-1] YTX-465
PRODUCTS SPECIFICATIONS [2225824-53-1]
DESCRIPTION [2225824-53-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 458.51 |
| Molecular Formula | C25H26N6O3 |
| SMILES | O=C(NCC(N1CCC(C2=NC(C3=CC4=C(C=C3)C(C)=NN4C)=NO2)CC1)=O)C5=CC=CC=C5 |
Summary
YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC 50 s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies [1] .
IC50 & Target
|
Ole1 0.039 μM (IC 50 ) |
SCD1 30.4 μM (IC 50 ) |
In Vitro
YTX-465 (1-10000 nM) has an EC
50
value of 0.013 μM for α-synuclein (α-syn) toxicity rescue
[1]
.
YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast
[1]
.
YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing
OLE1
in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop
[1]
.
YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM
[1]
.
YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 218.10 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1810 mL | 10.9049 mL | 21.8098 mL |
| 5 mM | 0.4362 mL | 2.1810 mL | 4.3620 mL |
| 10 mM | 0.2181 mL | 1.0905 mL | 2.1810 mL |
Synonyms