[CAS NO. 2226517-75-3]  Dynapyrazole-A

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PRODUCTS SPECIFICATIONS [2226517-75-3]

Catalog
HY-131873
Brand
MCE
CAS
2226517-75-3

DESCRIPTION [2226517-75-3]

Overview

MDL-
Molecular Weight486.69
Molecular FormulaC20H12ClIN4O
SMILESN#CC1=C(N2)N(N=C1C3(C4=CC=C(Cl)C=C4)CC3)C5=C(C=C(I)C=C5)C2=O

For research use only. We do not sell to patients.

Summary

Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity [1] .


In Vitro

Dynapyrazole A (1- 3 μg/mL, 14 h) reduces viral titers in MA-104 cells infected with RVA-NMTL virus in a dose-dependent manner with an EC 50 value of 0.73 μg/mL [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 51.37 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0547 mL 10.2735 mL 20.5470 mL
5 mM 0.4109 mL 2.0547 mL 4.1094 mL
10 mM 0.2055 mL 1.0273 mL 2.0547 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (5.14 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.14 mM); Clear solution

* All of the co-solvents are available by MCE.