[CAS NO. 223104-29-8] SEA0400

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PRODUCTS SPECIFICATIONS [223104-29-8]

Catalog

HY-15515

Brand

MCE

CAS

223104-29-8

DESCRIPTION [223104-29-8]

Overview

MDL	MFCD07772188
Molecular Weight	371.38
Molecular Formula	C21H19F2NO3
SMILES	NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2

For research use only. We do not sell to patients.

14 Publications Citing Use of MCE

Summary

SEA0400 is a novel and selective inhibitor of the Na ⁺ -Ca ²⁺ exchanger ( NCX ), inhibiting Na ⁺ -dependent Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia with IC ₅₀ s of from 5 to 33 nM.

IC50 & Target

IC50: 5-33 nM (NCX)

In Vitro

SEA0400 inhibits Na ⁺ -dependent ⁴⁵ Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia. IC ₅₀ values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia) ^[1] . SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca ²⁺ -dependent manner ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats ^[1] . SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 32 mg/mL ( 86.17 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6927 mL	13.4633 mL	26.9266 mL
5 mM	0.5385 mL	2.6927 mL	5.3853 mL
10 mM	0.2693 mL	1.3463 mL	2.6927 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (6.73 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

* All of the co-solvents are available by MCE.