[CAS NO. 2237268-90-3] Nampt activator-2

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PRODUCTS SPECIFICATIONS [2237268-90-3]

Catalog

HY-148822

Brand

MCE

CAS

2237268-90-3

DESCRIPTION [2237268-90-3]

Overview

MDL	-
Molecular Weight	390.84
Molecular Formula	C17H15ClN4O3S
SMILES	O=C(NCC1=CNN=C1)NC2=CC=C(S(=O)(C3=CC=C(C=C3)Cl)=O)C=C2

For research use only. We do not sell to patients.

Summary

Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC ₅₀ of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM) ^[1] .

In Vitro

Nampt activator-2 (compound 34) (10 μM, 4 h) results in a marked increase of both NMN and NAD in A549 lung epithelial cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt activator-2 (compound 34) (1 mg/kg iv and 10 mg/kg po, once) shows low plasma clearance, good exposure and excellent oral bioavailability (%F = 80) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse ^[1]

Dosage:

1 mg/kg iv and 10 mg/kg po

Administration:

IV, PO; once (Pharmacokinetic Analysis)

Result:

Pharmacokinetic Parameters of Nampt activator-2 in mouse ^[1] .

	IV (1 mg/kg)	PO (10 mg/kg)
C _max (ng/mL)		9550
AUC _0-24 (ng/mL∗h)		54463
t _1/2 (h)		3.2
CL (mL/min/kg)	3
Vd (L/kg)	0.61
F (%)		80

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References

[1] Pinkerton AB, et al. Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. Bioorg Med Chem Lett. 2021 Jun 1;41:128007.