[CAS NO. 22457-89-2] Benfotiamine

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PRODUCTS SPECIFICATIONS [22457-89-2]

Catalog

HY-17374

Brand

MCE

CAS

22457-89-2

DESCRIPTION [22457-89-2]

Overview

MDL	MFCD00057343
Molecular Weight	466.45
Molecular Formula	C19H23N4O6PS
SMILES	CC1=NC=C(CN(/C(C)=C(CCOP(O)(O)=O)/SC(C2=CC=CC=C2)=O)C=O)C(N)=N1

For research use only. We do not sell to patients.

Summary

Benfotiamine (S-Benzoylthiamine O-monophosphate) is an analog of vitamin B1 with higher absorption and bioavailability than vitamin B1, and is commonly used as a food supplement for diabetic complications. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage ^[1] ^[2] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02772926	Universidad de Guanajuato	Type 2 Diabetes Mellitus	October 2015	Not Applicable
NCT00565318	University Medical Center Groningen\|Isala\|Wörwag Pharma GmbH & Co. KG\|Predictions Network	Diabetic Nephropathy	December 2007	Phase 4
NCT00785460	Ruhr University of Bochum	Healthy Subjects	January 2008	Phase 3
NCT00437008	Ruhr University of Bochum	Endothelial Dysfunction\|Type 2 Diabetes Mellitus	November 2004	Phase 4
NCT01868191	Diabetes Schwerpunktpraxis\|Woerwag Pharma GmbH & Co. KG	Diabetic Neuropathies	July 2013	Phase 3
NCT02292238	Burke Medical Research Institute\|Burke Rehabilitation Hospital\|Columbia University\|National Institute on Aging (NIA)\|Alzheimer´s Drug Discovery Foundation\|Montefiore Medical Center	Alzheimer´s Disease	February 15, 2015	Phase 2
NCT00117026	University Hospital, Aker\|The Research Council of Norway\|Oslo University Hospital	Diabetes Mellitus, Type 1	August 2005	Phase 1\|Phase 2
NCT00446810	Ruhr University of Bochum	Diabetes Mellitus, Type 2	September 2007	Phase 4
NCT00680121	University of Kansas\|University of Kansas Medical Center	Alcoholism	July 2008	Phase 4

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL ( 107.19 mM )

H ₂ O : 0.67 mg/mL ( 1.44 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1439 mL	10.7193 mL	21.4385 mL
5 mM	0.4288 mL	2.1439 mL	4.2877 mL
10 mM	0.2144 mL	1.0719 mL	2.1439 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 3.12 mg/mL (6.69 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 3 mg/mL (6.43 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 3 mg/mL (6.43 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 3 mg/mL (6.43 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester

Benzoic acid, thio-, S-ester with N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester)

Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester

Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)-, S-benzoate O-(dihydrogen phosphate)

N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate

Benfotiamine

Benzoylthiamine monophosphate

Benzoylthiamine O-monophosphate

S-Benzoylthiamine monophosphate

S-Benzoylthiamine O-monophosphate

Biotamin

BTMP

Nitanevril

Neurostop

Vitanevril

Berdi

Betivina

Bietamine

Tabiomyl

Benfothiamine

8088CB

Milgamma