[CAS NO. 2245880-46-8] Avibactamtomilopil

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PRODUCTS SPECIFICATIONS [2245880-46-8]

Catalog

HY-132987

Brand

MCE

CAS

2245880-46-8

DESCRIPTION [2245880-46-8]

Overview

MDL	-
Molecular Weight	393.41
Molecular Formula	C14H23N3O8S
SMILES	NC([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(OCC(C)(C)C(OCC)=O)(=O)=O)=O)=O

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Avibactam tomilopil (ARX-1796, AV-006), an Avibactam prodrug, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes ^[1] ^[2] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03931876	Arixa Pharmaceuticals	Bacterial Infections	June 24, 2019	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 254.19 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5419 mL	12.7094 mL	25.4188 mL
5 mM	0.5084 mL	2.5419 mL	5.0838 mL
10 mM	0.2542 mL	1.2709 mL	2.5419 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution

* All of the co-solvents are available by MCE.