[CAS NO. 2248003-71-4] AZD3229Tosylate
PRODUCTS SPECIFICATIONS [2248003-71-4]
DESCRIPTION [2248003-71-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 651.71 |
| Molecular Formula | C31H34FN7O6S |
| SMILES | COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1.CC5=CC=C(S(O)(=O)=O)C=C5 |
Summary
AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.
IC50 & Target
KIT [1] .
In Vitro
AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI 50 =1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 153.44 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5344 mL | 7.6721 mL | 15.3442 mL |
| 5 mM | 0.3069 mL | 1.5344 mL | 3.0688 mL |
| 10 mM | 0.1534 mL | 0.7672 mL | 1.5344 mL |
Synonyms