[CAS NO. 2262452-06-0] RU.521

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PRODUCTS SPECIFICATIONS [2262452-06-0]

Catalog

HY-114180

Brand

MCE

CAS

2262452-06-0

DESCRIPTION [2262452-06-0]

Overview

MDL	-
Molecular Weight	415.23
Molecular Formula	C19H12Cl2N4O3
SMILES	O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5

For research use only. We do not sell to patients.

10 Publications Citing Use of MCE

Summary

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC ₅₀ of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) ^[1] .

IC50 & Target

IC50: 0.7 μM (dsDNA) ^[1]

In Vitro

RU.521 (0.1 nM-1000 μM; 72 h) suppresses dsDNA-induced signaling in macrophage cells ^[1] .
RU.521(0-100 μM; 24 h) selectively inhibits cGAS-mediated signaling ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RU.521 (5 mg/kg ; i.p. once) reduces symptoms from sepsis in mice ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male 8-week-old male mice with LPS injection ^[2]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg once
Result:	Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL ( 200.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4083 mL	12.0415 mL	24.0830 mL
5 mM	0.4817 mL	2.4083 mL	4.8166 mL
10 mM	0.2408 mL	1.2042 mL	2.4083 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution

* All of the co-solvents are available by MCE.