[CAS NO. 22662-39-1] Rafoxanide

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PRODUCTS SPECIFICATIONS [22662-39-1]

Catalog

HY-17598

Brand

MCE

CAS

22662-39-1

DESCRIPTION [22662-39-1]

Overview

MDL	MFCD00682899
Molecular Weight	626.01
Molecular Formula	C19H11Cl2I2NO3
SMILES	O=C(NC1=CC=C(OC2=CC=C(Cl)C=C2)C(Cl)=C1)C3=CC(I)=CC(I)=C3O

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide can be used for the control of infestation with Hemonchus species and Fasciola species in sheep and cattle and Estrus ovis in sheep. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide eliminates 91-99% of the mature flukes and 50-90% of the younger flukes in ruminants ^[1] ^[2] ^[3] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 31 mg/mL ( 49.52 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5974 mL	7.9871 mL	15.9742 mL
5 mM	0.3195 mL	1.5974 mL	3.1948 mL
10 mM	0.1597 mL	0.7987 mL	1.5974 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzamide, N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-

Salicylanilide, 3′-chloro-4′-(p-chlorophenoxy)-3,5-diiodo-

N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide

Rafoxanide

3,5-Diiodo-3′-chloro-4′-(p-chlorophenoxy)salicylanilide

3,5-Diodo-3′-chloro-4′-(p-chlorophenoxy)salicylanilide

Ranide

3′-Chloro-4′-(p-chlorophenoxy)-3,5-diiodosalicylanilide

3′-Chloro-4′-(4-chlorophenoxy)-3,5-diiodosalicylanilide

Disalan

NSC 355278