[CAS NO. 2292116-14-2] DesmorpholinylQuizartinib-PEG2-COOH

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2292116-14-2]

Catalog

HY-131230

Brand

MCE

CAS

2292116-14-2

DESCRIPTION [2292116-14-2]

Overview

MDL	-
Molecular Weight	607.68
Molecular Formula	C30H33N5O7S
SMILES	O=C(O)CCOCCOCCOC1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(NC(NC5=NOC(C(C)(C)C)=C5)=O)C=C4)=C3

For research use only. We do not sell to patients.

Summary

Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3 , and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC ₅₀ 0.6 nM ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.