[CAS NO. 2369053-68-7] SMARCA-BDligand1forPROTACdihydrochloride

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2369053-68-7]

Catalog

HY-44012A

Brand

MCE

CAS

2369053-68-7

DESCRIPTION [2369053-68-7]

Overview

MDL	-
Molecular Weight	344.24
Molecular Formula	C14H19Cl2N5O
SMILES	OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl.[H]Cl

For research use only. We do not sell to patients.

Summary

SMARCA-BD ligand 1 for Protac dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC ^[1] .

IC50 & Target

SMARCA2 ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 2.7 mg/mL ( 7.84 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9050 mL	14.5248 mL	29.0495 mL
5 mM	0.5810 mL	2.9050 mL	5.8099 mL
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.