[CAS NO. 2369751-07-3] G140
PRODUCTS SPECIFICATIONS [2369751-07-3]
DESCRIPTION [2369751-07-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 379.24 |
| Molecular Formula | C17H16Cl2N4O2 |
| SMILES | OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O |
Summary
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity [1] .
IC50 & Target
IC50: 14.0 nM (h-cGAS), 442 nM (m-cGAS) [1]
In Vitro
G140 (0.1-100 µM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC
50
s of 1.70 and 0.86 µM in human THP1 and primary macrophages, respectively
[1]
.
G140 (0.1-100 µM; 24 h) inhibits cells viability with a LD
50
of >100 µM in THP1 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 659.21 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6369 mL | 13.1843 mL | 26.3685 mL |
| 5 mM | 0.5274 mL | 2.6369 mL | 5.2737 mL |
| 10 mM | 0.2637 mL | 1.3184 mL | 2.6369 mL |