[CAS NO. 2373065-59-7]  DS12881479

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PRODUCTS SPECIFICATIONS [2373065-59-7]

Catalog
HY-148105
Brand
MCE
CAS
2373065-59-7

DESCRIPTION [2373065-59-7]

Overview

MDL-
Molecular Weight301.41
Molecular FormulaC16H19N3OS
SMILESO=C(C1CCN(C)CC1)NC2=NC=C(C3=CC=CC=C3)S2

For research use only. We do not sell to patients.

Summary

DS12881479 is a potent and selective Mnk1 inhibitor with an IC 50 value of 21 nM. DS12881479 can be used in cancer research [1] .


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 829.43 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3177 mL 16.5887 mL 33.1774 mL
5 mM 0.6635 mL 3.3177 mL 6.6355 mL
10 mM 0.3318 mL 1.6589 mL 3.3177 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (6.90 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.90 mM); Clear solution

* All of the co-solvents are available by MCE.