[CAS NO. 2375070-79-2] MS48107
PRODUCTS SPECIFICATIONS [2375070-79-2]
DESCRIPTION [2375070-79-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 417.44 |
| Molecular Formula | C23H20FN5O2 |
| SMILES | OCC1=CC=CC(F)=C1C2=NC(N)=NC(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=N2 |
Summary
MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68) . MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice [1] .
In Vitro
5-HT2B has moderate binding affinity to MS48107 (compound 71) with a K
i
value of 219 nM. At 5-HT2B receptors, MS48107 shows no agonist activity but display weak antagonist activity with a K
i
value of 310 nM, respectively
[1]
.
MS48107 (compound 71) has agonist activity only at the MT1 and MT2 receptors. MS48107 is a weak full agonist at the MT1 receptor (EC
50
= 320 nM) and a weak partial agonist activity at the MT2 receptor (EC
50
= 540 nM). MS48107 displays low binding affinities to MT1 (5900 nM) and MT2 (1100 nM) receptors
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
For MS48107 (compound 71), a single intraperitoneal injection at the dose of 25 mg/kg leads to high exposure levels (above 10 μM) in both plasma and brain at 0.5 h in mice (Swiss Albino mice). The high compound exposure levels in both plasma and brain are maintained for 2 h [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 239.56 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3956 mL | 11.9778 mL | 23.9555 mL |
| 5 mM | 0.4791 mL | 2.3956 mL | 4.7911 mL |
| 10 mM | 0.2396 mL | 1.1978 mL | 2.3956 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.99 mM); Clear solution