[CAS NO. 2378173-15-8] PF-06928215
PRODUCTS SPECIFICATIONS [2378173-15-8]
DESCRIPTION [2378173-15-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 380.40 |
| Molecular Formula | C20H20N4O4 |
| SMILES | OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[C@H]4CCCC[C@H]4C(O)=O)=O)C=NN13 |
3 Publications Citing Use of MCE
Summary
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC 50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM ( K d ) [1] .
In Vitro
PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 87.62 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6288 mL | 13.1441 mL | 26.2881 mL |
| 5 mM | 0.5258 mL | 2.6288 mL | 5.2576 mL |
| 10 mM | 0.2629 mL | 1.3144 mL | 2.6288 mL |