[CAS NO. 2378261-83-5] K-Rasligand-LinkerConjugate4
PRODUCTS SPECIFICATIONS [2378261-83-5]
DESCRIPTION [2378261-83-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 697.82 |
| Molecular Formula | C35H51N7O8 |
| SMILES | O=C(N1[C@@H](CC#N)CN(C2=C3C(CNCC3)=NC(OC[C@H]4N(C)C[C@H](OCCOCCOCCOCCO)C4)=N2)CC1)OCC5=CC=CC=C5 |
Summary
K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2 , and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells [1] .
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
Ethanol : 50 mg/mL ( 71.65 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.4330 mL | 7.1652 mL | 14.3303 mL |
| 5 mM | 0.2866 mL | 1.4330 mL | 2.8661 mL |
| 10 mM | 0.1433 mL | 0.7165 mL | 1.4330 mL |
References