[CAS NO. 24063-71-6] Isocurcumenol
PRODUCTS SPECIFICATIONS [24063-71-6]
DESCRIPTION [24063-71-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 234.33 |
| Molecular Formula | C15H22O2 |
| SMILES | O[C@@]1(C2)/C(C[C@]3(O1)[C@@H](C)CC[C@@]3([H])C2=C)=C(C)/C |
1 Publications Citing Use of MCE
Summary
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC 50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively [1] [2] .
In Vitro
Isocurcumenol (12.5-400 µg/mL, 24-48 h) dose-dependently inhibits cancer cells proliferation
[1]
.
isocurcumenol does not exhibit any significant toxicity on normal chicken embryo fibroblast cells and lymphocytes
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 426.75 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.2675 mL | 21.3374 mL | 42.6749 mL |
| 5 mM | 0.8535 mL | 4.2675 mL | 8.5350 mL |
| 10 mM | 0.4267 mL | 2.1337 mL | 4.2675 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution
References
- [1] Lakshmi S, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. Int J Med Chem. 2011;2011:253962.
- [2] Resmi Mustarichiei, et al. In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer. Basic Medical Research. 2014
Synonyms