[CAS NO. 2414349-93-0] UGT8-IN-1
PRODUCTS SPECIFICATIONS [2414349-93-0]
DESCRIPTION [2414349-93-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 528.47 |
| Molecular Formula | C20H22F6N4O4S |
| SMILES | O=C(OC1CCN(C2=CC(C(F)(F)F)=C3C(C(C(NC)=O)=CS3)=N2)CC1)N[C@@H](C)COC(F)(F)F |
Summary
UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8) . UGT8-IN-1 can be used in the study for lysosomal storage disorders [1] .
In Vivo
UGT8-IN-1 (compound 19) exhibits the T1/2 of 4.3 h, 1.13 h and 13.6 h by iv (1 mg/kg) administration in rat, mouse and dog, respectively. UGT8-IN-1 (compound 19) shows F% of 40%, 34% and 52% by oral (3 mg/kg) administration in rat, mouse and dog, respectively
[1]
.
UGT8-IN-1 (compound 19, orally twice a day for three days) shows ≥90% inhibition of incorporation of
13
C-Gal into GalCer and SFT, at all three doses tested, with the estimated ED
50
s of <3 mg/kg for inhibition of both SFT and GalCer. UGT8-IN-1 (compound 19) has very high plasma protein and tissue binding (>99%)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 115 mg/mL ( 217.61 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8923 mL | 9.4613 mL | 18.9226 mL |
| 5 mM | 0.3785 mL | 1.8923 mL | 3.7845 mL |
| 10 mM | 0.1892 mL | 0.9461 mL | 1.8923 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 5.75 mg/mL (10.88 mM); Clear solution