[CAS NO. 2417370-39-7] PROTACBRD4Degrader-24

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PRODUCTS SPECIFICATIONS [2417370-39-7]

Catalog

HY-129938

Brand

MCE

CAS

2417370-39-7

DESCRIPTION [2417370-39-7]

Overview

MDL	-
Molecular Weight	1306.58
Molecular Formula	C62H77F2N9O12S4
SMILES	O=C(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O)=O

For research use only. We do not sell to patients.

Summary

PROTAC BRD4 degrader for PAC-1 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 76.54 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7654 mL	3.8268 mL	7.6536 mL
5 mM	0.1531 mL	0.7654 mL	1.5307 mL
10 mM	0.0765 mL	0.3827 mL	0.7654 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.