[CAS NO. 24356-66-9] Vidarabine monohydrate

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PRODUCTS SPECIFICATIONS [24356-66-9]

Catalog

HY-N6666

Brand

MCE

CAS

24356-66-9

DESCRIPTION [24356-66-9]

Overview

MDL	MFCD00150980
Molecular Weight	285.26
Molecular Formula	C10H15N5O5
SMILES	O[C@H]1[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1CO.O

For research use only. We do not sell to patients.

5 Publications Citing Use of MCE

Summary

Vidarabine monohydrate is an adenine arabinoside. Vidarabine monohydrate an antiviral drug which is active against herpes simplex viruses ( HSV ) and varicella zoster viruses ^[1] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00000985	National Institute of Allergy and Infectious Diseases (NIAID)	Herpes Simplex\|HIV Infections		Phase 3

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 876.39 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5056 mL	17.5279 mL	35.0557 mL
5 mM	0.7011 mL	3.5056 mL	7.0111 mL
10 mM	0.3506 mL	1.7528 mL	3.5056 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Whitley, R., et al., Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs, 1980. 20(4): p. 267-82.

Synonyms

9H-Purin-6-amine, 9-β-D-arabinofuranosyl-, hydrate (1:1)

Adenine, 9-β-D-arabinofuranosyl-, monohydrate

9H-Purin-6-amine, 9-β-D-arabinofuranosyl-, monohydrate

Adenine arabinofuranoside hydrate

Vidarabine monohydrate