[CAS NO. 2436747-44-1] Bobcat339 hydrochloride
PRODUCTS SPECIFICATIONS [2436747-44-1]
DESCRIPTION [2436747-44-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 334.20 |
| Molecular Formula | C16H13Cl2N3O |
| SMILES | NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O.Cl |
7 Publications Citing Use of MCE
Summary
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme , with the IC 50 s of 33 μM and 73 μM for TET1 and TET2 , respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1] .
IC50 & Target
IC50: 33 μM (TET1), 73 μM (TET2) [1]
In Vitro
Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 130 mg/mL ( 388.99 mM ; Need ultrasonic)
H 2 O : 0.1 mg/mL ( 0.30 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9922 mL | 14.9611 mL | 29.9222 mL |
| 5 mM | 0.5984 mL | 2.9922 mL | 5.9844 mL |
| 10 mM | 0.2992 mL | 1.4961 mL | 2.9922 mL |