[CAS NO. 2438-72-4] Bufexamac
PRODUCTS SPECIFICATIONS [2438-72-4]
DESCRIPTION [2438-72-4]
Overview
| MDL | MFCD00078936 |
|---|---|
| Molecular Weight | 223.27 |
| Molecular Formula | C12H17NO3 |
| SMILES | O=C(NO)CC1=CC=C(OCCCC)C=C1 |
1 Publications Citing Use of MCE
Summary
Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent.
IC50 & Target
|
HDAC6 10.7 μM (Kd app) |
HDAC10 12.3 μM (Kd app) |
HDAC8 235 μM (Kd app) |
HDAC3 341 μM (Kd app) |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 447.89 mM )
H 2 O : 0.67 mg/mL ( 3.00 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.4789 mL | 22.3944 mL | 44.7888 mL |
| 5 mM | 0.8958 mL | 4.4789 mL | 8.9578 mL |
| 10 mM | 0.4479 mL | 2.2394 mL | 4.4789 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (44.79 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (11.20 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (11.20 mM); Clear solution
References
- [1] Bantscheff, M., et al., Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol, 2011. 29(3): p. 255-65.
- [2] Kranke, B., et al., Epidemiological significance of bufexamac as a frequent and relevant contact sensitizer. Contact Dermatitis, 1997. 36(4): p. 212-5.
Synonyms