[CAS NO. 2489320-03-6] Protein kinase D inhibitor 1
PRODUCTS SPECIFICATIONS [2489320-03-6]
DESCRIPTION [2489320-03-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 347.42 |
| Molecular Formula | C19H21N7 |
| SMILES | NC1=C2C(N(CC3CCNCC3)N=C2C4=CNC5=C4C=CC=C5)=NC=N1 |
Summary
IC50 & Target
|
PKD3 17 ± 8 nM (IC 50 ) |
PKD2 35 ± 5 nM (IC 50 ) |
PKD1 35 ± 10 nM (IC 50 ) |
In Vitro
Protein kinase D inhibitor 1 (compound 17m) displays excellent PKD2 inhibition with almost no remaining kinase activity at 1 μM
[1]
.
Protein kinase D inhibitor 1 displays only weak antiproliferative activity, and does not significantly affect PANC-1 cell proliferation at a concentration of 5 μM
[1]
.
Protein kinase D inhibitor 1 (0-100 μM, 72 h) shows antitumor activity
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, K-562 |
| Concentration: | 0-100 μM |
| Incubation Time: | 72 h |
| Result: | Inhibited of tumor cell growth of LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, and K-562, with IC 50 values of 80.6 ± 7, 40.7 ± 14.5, 42.7 ± 4.9, 17.9 ± 4.1, 35.3 ± 10.4, >95.8, >100, and >100, respectively. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.