[CAS NO. 2491-38-5] 2-Bromo-4'-hydroxyacetophenone

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PRODUCTS SPECIFICATIONS [2491-38-5]

Catalog

HY-W002314

Brand

MCE

CAS

2491-38-5

DESCRIPTION [2491-38-5]

Overview

MDL	MFCD00072424
Molecular Weight	215.04
Molecular Formula	C8H7BrO2
SMILES	OC1=CC=C(C(CBr)=O)C=C1

For research use only. We do not sell to patients.

Summary

2-Bromo-4'-hydroxyacetophenone a PTP1B inhibitor, with a K _i of 42 μM ^[1] .

IC50 & Target

Ki: 42 μM (PTP1B) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 1162.57 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6503 mL	23.2515 mL	46.5030 mL
5 mM	0.9301 mL	4.6503 mL	9.3006 mL
10 mM	0.4650 mL	2.3251 mL	4.6503 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (9.67 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (9.67 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (9.67 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Sidhu, Alban, et al. Toward Inhibitors of Protein Tyrosine Phosphatases for Cancer Treatment. Home / Current Enzyme Inhibition, Volume 4, Number 1.

Synonyms

Ethanone, 2-bromo-1-(4-hydroxyphenyl)-

Acetophenone, 2-bromo-4′-hydroxy-

2-Bromo-1-(4-hydroxyphenyl)ethanone

2-Bromo-4′-hydroxyacetophenone

Busan 90

p-Hydroxyphenacyl bromide

4′-Hydroxy-2-bromoacetophenone

4-Hydroxyphenacyl bromide

α-Bromo-4′-hydroxyacetophenone

α-Bromo-p-hydroxyacetophenone

ω-Bromo-p-hydroxyacetophenone

1-(4-Hydroxyphenyl)-2-bromoethanone

Busan 1130

2-Bromo-1-(4-hydroxyphenyl)ethan-1-one

Butrol 1130