[CAS NO. 2505078-08-8] Elenestinib

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PRODUCTS SPECIFICATIONS [2505078-08-8]

Catalog

HY-152839

Brand

MCE

CAS

2505078-08-8

DESCRIPTION [2505078-08-8]

Overview

MDL	-
Molecular Weight	528.58
Molecular Formula	C27H29FN10O
SMILES	OCCN1C=C(C=N1)C2=CN3N=CN=C(N4CCN(C5=NC=C([C@@](N)(C6=CC=C(C=C6)F)C)C=N5)CC4)C3=C2

For research use only. We do not sell to patients.

Summary

Elenestinib (BLU-263) is a potent and orally active tyrosine kinase inhibitor. Elenestinib has the potential for the research of systemic mastocytosis (SM) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 236.48 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8919 mL	9.4593 mL	18.9186 mL
5 mM	0.3784 mL	1.8919 mL	3.7837 mL
10 mM	0.1892 mL	0.9459 mL	1.8919 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 6.25 mg/mL (11.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Mariana Castells, et al. A Phase 2/3 Study of BLU-263 in Patients with Indolent Systemic Mastocytosis or Monoclonal Mast Cell Activation Syndrome. Allergy and Clinical Immunology. 2022, 149 (2).