[CAS NO. 2505339-54-6] BR102910
PRODUCTS SPECIFICATIONS [2505339-54-6]
DESCRIPTION [2505339-54-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 459.30 |
| Molecular Formula | C18H14Cl2F2N4O2S |
| SMILES | O=C(C1=CSC(CC2=CC=C(Cl)C(Cl)=C2)=N1)NCC(N3[C@H](C#N)CC(F)(F)C3)=O |
Summary
BR102910 is a selective fibroblast activation protein ( FAP ) inhibitor with the IC 50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC 50 of 49.00 μM. BR102910 can be used for the researchof type 2
IC50 & Target
IC50: 2 nM (FAP), 49.0 μM (PREP), >100 μM (DPP-4) [1]
In Vivo
BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/6J mice (n = 5 per group) [1] |
| Dosage: | 0, 10 and 30 mg/kg |
| Administration: | Orally, once |
| Result: | Showed significant FAP inhibition in a dose dependent manner. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)