[CAS NO. 2511248-11-4] DHODH-IN-16
PRODUCTS SPECIFICATIONS [2511248-11-4]
DESCRIPTION [2511248-11-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 436.48 |
| Molecular Formula | C24H25FN4O3 |
| SMILES | O=C1C2=C(C(C(C)C)=CN1C3=C(C)C=CC=C3)C=C(N4N=C(CO)N(CC)C4=O)C(F)=C2 |
Summary
DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC 50 of 0.396 nM for human DHODH [1] .
IC50 & Target
IC50: 0.396 nM (human DHODH) [1]
In Vitro
DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC 50 of 0.2 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 229.11 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2911 mL | 11.4553 mL | 22.9106 mL |
| 5 mM | 0.4582 mL | 2.2911 mL | 4.5821 mL |
| 10 mM | 0.2291 mL | 1.1455 mL | 2.2911 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution