[CAS NO. 25122-57-0] Clobetasone butyrate
PRODUCTS SPECIFICATIONS [25122-57-0]
DESCRIPTION [25122-57-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 478.98 |
| Molecular Formula | C26H32ClFO5 |
| SMILES | C[C@@]1(C2)[C@](C(CCl)=O)(OC(CCC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)C2=O)=O |
1 Publications Citing Use of MCE
Summary
Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis [1] .
IC50 & Target
IC50: glucocorticoid [1]
In Vivo
Clobetasone butyrate (application on the skin; 0.05%; 7 weeks) induces epidermal thinning in skin, Clobetasone butyrate 7 weeks causes much less epidermal thinning in the pig than flurandrenolone (0.05%) or fluocinolone acetonide (0.025%), both of which causes severe atrophy
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Large white domestic pig [1] |
| Dosage: | 0.5% application on the skin |
| Administration: | 7 weeks |
| Result: | Caused moderate to slight atrophy. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01567995 | GlaxoSmithKline |
Eczema
|
February 28, 2008 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 250 mg/mL ( 521.94 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0878 mL | 10.4388 mL | 20.8777 mL |
| 5 mM | 0.4176 mL | 2.0878 mL | 4.1755 mL |
| 10 mM | 0.2088 mL | 1.0439 mL | 2.0878 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 6.25 mg/mL (13.05 mM); Clear solution
References
Synonyms