[CAS NO. 251994-14-6] ICAM-1-IN-1
PRODUCTS SPECIFICATIONS [251994-14-6]
DESCRIPTION [251994-14-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 363.23 |
| Molecular Formula | C15H11BrN2O2S |
| SMILES | O=C(C(S1)=CC2=C1C=NC=C2OC3=CC=C(Br)C=C3)NC |
Summary
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC 50 values of 7 and 5 nM, respectively.
IC50 & Target
IC50: 7 nM (E-selectin), 5 nM (ICAM-1) [1]
In Vivo
ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 135 mg/mL ( 371.67 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7531 mL | 13.7654 mL | 27.5308 mL |
| 5 mM | 0.5506 mL | 2.7531 mL | 5.5062 mL |
| 10 mM | 0.2753 mL | 1.3765 mL | 2.7531 mL |