[CAS NO. 25526-93-6] Alovudine

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PRODUCTS SPECIFICATIONS [25526-93-6]

Catalog

HY-B1516

Brand

MCE

CAS

25526-93-6

DESCRIPTION [25526-93-6]

Overview

MDL	MFCD00056058
Molecular Weight	244.22
Molecular Formula	C10H13FN2O4
SMILES	O=C(N1)N([C@H]2C[C@H](F)[C@@H](CO)O2)C=C(C)C1=O

For research use only. We do not sell to patients.

Summary

3'-Fluoro-3'-deoxythymidine (Alovudine) is a marker of DNA synthesis that is less susceptible to inflammatory changes than ¹⁸ F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer . 3'-Fluoro-3'-deoxythymidine shows anti-orthopoxvirus activity ^[1] ^[2] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00002254	Lederle Laboratories\|NIH AIDS Clinical Trials Information Service	HIV Infections		Not Applicable
NCT00002271	Lederle Laboratories\|NIH AIDS Clinical Trials Information Service	HIV Infections		Not Applicable
NCT00002260	Lederle Laboratories\|NIH AIDS Clinical Trials Information Service	HIV Infections		Not Applicable
NCT02232581	Boehringer Ingelheim	HIV Infections	April 2004	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 511.83 mM ; Need ultrasonic)

H ₂ O : ≥ 25 mg/mL ( 102.37 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0947 mL	20.4733 mL	40.9467 mL
5 mM	0.8189 mL	4.0947 mL	8.1893 mL
10 mM	0.4095 mL	2.0473 mL	4.0947 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Thymidine, 3′-deoxy-3′-fluoro-

3′-Deoxy-3′-fluorothymidine

1-(3′-Deoxy-3′-fluoro-β-D-pentofuranosyl)thymine

3′-Fluorodeoxythymidine

3′-Fluorothymidine

3′-Fluoro-3′-deoxythymidine

FLT

Alovudine

CL 184824

NSC 140025

MIV 310

3′-Fluoro-2′,3′-dideoxythymidine