[CAS NO. 2566-34-9] MeAIB

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PRODUCTS SPECIFICATIONS [2566-34-9]

Catalog

HY-134452

Brand

MCE

CAS

2566-34-9

DESCRIPTION [2566-34-9]

Overview

MDL	MFCD00004191
Molecular Weight	117.15
Molecular Formula	C5H11NO2
SMILES	CC(C)(NC)C(O)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Cell Metab. 2022 Sep 7;S1550-4131(22)00359-X.

Summary

MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1) . ATA mediate the uptake of short-chain neutral amino acids in a Na ⁺ -dependent manner ^[1] .

In Vitro

ATA3 is a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. ATA1 (also known as GlnT) and ATA2 (also known as SAT2), have been cloned from rat and human tissues. These transporters mediate the uptake of short-chain neutral amino acids in a Na ⁺ -dependent manner ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02232672	Odense University Hospital	Prostate Cancer	November 2016	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H ₂ O : 100 mg/mL ( 853.61 mM ; Need ultrasonic)

DMSO : 50 mg/mL ( 426.80 mM ; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.5361 mL	42.6803 mL	85.3606 mL
5 mM	1.7072 mL	8.5361 mL	17.0721 mL
10 mM	0.8536 mL	4.2680 mL	8.5361 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (853.61 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (21.34 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (21.34 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (21.34 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Alanine, N,2-dimethyl-

N,2-Dimethylalanine

N-Methyl-α-aminoisobutyric acid

α-(Methylamino)isobutyric acid

2-(N-Methylamino)isobutyric acid

N-Methyl-2-amino-isobutyric acid

N-Methyl-2-methylalanine

2-(Methylamino)isobutyric acid

2-Methyl-2-(methylamino)propanoic acid