[CAS NO. 2586-60-9] Direct Violet 1

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PRODUCTS SPECIFICATIONS [2586-60-9]

Catalog

HY-D1270

Brand

MCE

CAS

2586-60-9

DESCRIPTION [2586-60-9]

Overview

MDL	MFCD00046486
Molecular Weight	728.66
Molecular Formula	C32H22N6Na2O8S2
SMILES	O=S(C1=CC(O)=C2C(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(N)C=CC6=CC(S(=O)(O[Na])=O)=CC(O)=C56)C=C4)C=C3)=C(N)C=CC2=C1)(O[Na])=O

For research use only. We do not sell to patients.

Summary

Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC ₅₀ s of 1.47-2.63 µM ^[1] ^[2] .

IC50 & Target

IC50: 1.47 µM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 µM (SARS-CoV-S1S2 binding to ACE2); 2.11 µM (TNF-R1-TNFα binding) ^[1]

In Vitro

Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC ₅₀ values of 1.47 µM, 2.63 µM, and 2.11 µM, respectively ^[1] .
Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC ₅₀ of 35.8 µM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 62.5 mg/mL ( 85.77 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3724 mL	6.8619 mL	13.7238 mL
5 mM	0.2745 mL	1.3724 mL	2.7448 mL
10 mM	0.1372 mL	0.6862 mL	1.3724 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

2-Naphthalenesulfonic acid, 5,5′-[[1,1′-biphenyl]-4,4′-diylbis(2,1-diazenediyl)]bis[6-amino-4-hydroxy-, sodium salt (1:2)

C.I. Direct Violet 1, disodium salt

2-Naphthalenesulfonic acid, 5,5′-[[1,1′-biphenyl]-4,4′-diylbis(azo)]bis[6-amino-4-hydroxy-, disodium salt

C.I. Direct Violet 1

Direct Violet

C.I. 22570

Airedale Violet ND

Amanil Fast Violet N

Atlantic Violet N

Atul Direct Violet N

Azocard Violet N

Bencidal Fast Violet N

Benzanil Violet N

Benzo Violet N

Brasilamina Violet 3R

Calcomine Violet N

Chlorazol Violet N

Cotton Violet R

Diamine Violet N

Diaphtamine Violet N

Diazine Violet N

Diazol Violet N

Direct Brilliant Violet 2R

Direct Fast Violet N

Direct Fast Violet MN

Direct Violet C

Direct Violet N

Direct Violet FR

Erie Violet 3R

Fixanol Violet N

Hispamin Violet 3R

Japanol Violet J

Naphtamine Violet N

Paramine Fast Violet N

Pheno Violet N

Pontamine Violet N

Tertrodirect Violet N

Trisulfon Violet N

Direct Violet R

Direct Violet 1