[CAS NO. 2598242-66-9] NG-497

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PRODUCTS SPECIFICATIONS [2598242-66-9]

Catalog

HY-148756

Brand

MCE

CAS

2598242-66-9

DESCRIPTION [2598242-66-9]

Overview

MDL	-
Molecular Weight	315.36
Molecular Formula	C18H21NO4
SMILES	O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C

For research use only. We do not sell to patients.

Summary

NG-497 is a selective human adipose triglyceride lipase ( ATGL ) inhibitor that targets the enzymatically active patatin-like domain of human ATGL . NG-497 has potential value for tumor research ^[1] .

In Vitro

NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases and abolishes human adipocytes in a dose-dependent and reversible manner Lipolysis ^[1] .
NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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References

[1] Gernot F Grabner, et al. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. J Am Chem Soc. 2022 Apr 13;144(14):6237-6250.