[CAS NO. 260413-62-5] Ligustroflavone

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PRODUCTS SPECIFICATIONS [260413-62-5]

Catalog

HY-N0546

Brand

MCE

CAS

260413-62-5

DESCRIPTION [260413-62-5]

Overview

MDL	MFCD22125004
Molecular Weight	724.66
Molecular Formula	C33H40O18
SMILES	O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO[C@H](O[C@@H](C)[C@H](O)[C@H]3O)[C@@H]3O)[C@@H](O)[C@@H]4O)[C@@H]4O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)=C6)C2=C6O

For research use only. We do not sell to patients.

Summary

Ligustroflavone, extracted from Ligustrum lucidum , is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice ^[1] .

IC50 & Target

CaSR ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 172.49 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3800 mL	6.8998 mL	13.7996 mL
5 mM	0.2760 mL	1.3800 mL	2.7599 mL
10 mM	0.1380 mL	0.6900 mL	1.3800 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (2.87 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (2.87 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Feng R, et al. Protective Effects of Ligustroflavone, an Active Compound from Ligustrum lucidum, on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist. Am J Chin Med. 2019;47(2):457-476.