[CAS NO. 2677786-61-5] GRK6-IN-1
PRODUCTS SPECIFICATIONS [2677786-61-5]
DESCRIPTION [2677786-61-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 438.91 |
| Molecular Formula | C22H23ClN6O2 |
| SMILES | COC1=CC=CC2=NC(NCC3=CC=C(Cl)C=C3OC)=NC(NC4=NNC(CC)=C4)=C12 |
Summary
GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 ( GRK6 ) with an IC 50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 113.92 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2784 mL | 11.3919 mL | 22.7837 mL |
| 5 mM | 0.4557 mL | 2.2784 mL | 4.5567 mL |
| 10 mM | 0.2278 mL | 1.1392 mL | 2.2784 mL |