[CAS NO. 270249-38-2] (2S)-2'-Methoxykurarinone

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [270249-38-2]

Catalog

HY-N1746

Brand

MCE

CAS

270249-38-2

DESCRIPTION [270249-38-2]

Overview

MDL	-
Molecular Weight	452.54
Molecular Formula	C27H32O6
SMILES	O=C1C[C@@H](C2=CC=C(O)C=C2OC)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(OC)=C13

For research use only. We do not sell to patients.

Summary

(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens , has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells ^[1] ^[2] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 55.24 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2097 mL	11.0487 mL	22.0975 mL
5 mM	0.4419 mL	2.2097 mL	4.4195 mL
10 mM	0.2210 mL	1.1049 mL	2.2097 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.52 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.