[CAS NO. 2705841-53-6] 8RK59
PRODUCTS SPECIFICATIONS [2705841-53-6]
DESCRIPTION [2705841-53-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 688.60 |
| Molecular Formula | C33H39BF2N10O2S |
| SMILES | O=C(N1CC2=C(N=C(S2)NC([C@@H]3CN(CC3)C#N)=O)CC1)CN(N=N4)C=C4CCCCC(C5=C(C)C=C(C)[N-]5[B+3]([F-])6[F-])=C7[N]6=C(C)C=C7C |
Summary
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC 50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry , resulting in compound 8RK59 [1] .
IC50 & Target
UCHL1 (ubiquitin C-terminal hydrolase L1) [1]
In Vitro
8RK59 (5 μM, 24 h) binds only to wild-type UCHL1 but not to catalytically inactive UCHL1, indicating that the probe binding site is the active-site cysteine [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.