[CAS NO. 2719690-99-8] AZ7550-d 5
PRODUCTS SPECIFICATIONS [2719690-99-8]
DESCRIPTION [2719690-99-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 490.61 |
| Molecular Formula | C27H26D5N7O2 |
| SMILES | O=C(NC1=CC(NC2=NC=CC(C3=CN(C([2H])([2H])[2H])C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)/C=C([2H])\[2H] |
Summary
AZ7550-d 5 is the deuterium labeled AZ7550 (HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of IGF1R with an IC50 of 1.6 μM[1][2].
In Vitro
AZ7550-d5 (compound M6) has the relative abundance of metabolites generated in human liver microsomes of 15.58% [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937.
- [2] Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.